Equities markets were lower in London on Wednesday.
The FTSE 100 dropped 0.68 percent to 6,454.3, while the FTSE 250 was down 1.46 percent to 11,415.2.
Pharmaceutical group GlaxoSmithKline (LSE: GSK; NYSE: GSK) topped the 100, adding 2.33 percent to £12.75 on an unexpected increase in second quarter profits based on greater demand for its Advair asthma treatment.
GSK also announced an expansion of its share buy-back program.
Meanwhile on the 250, electronics and engineering group Renishaw (LSE: RSW), which makes gauges and meters, was the top performer with a gain of 14.33 percent to 684p/
Other gainers on the day included the banking sector.
On the 100, Northern Rock (LSE: NRK) added 1.87 percent to 817p, while on the 250 Bradford & Bingley (LSE: BB) gained 0.97 percent to 416.75p and Close Brothers Group (LSE: CBG) was up 1.93 percent to 845p.
Defense aerospace group BAE Systems (LSE: BA; OTCBB: BAESY) was 1.63 percent higher to 435.25p.
On the losing side, British Energy had the worst day on the 100, dropping 5.21 percent to 483.5p on a broker downgrade.
The worst performer on the 250 came from the semiconductors sector, where CSR (LSE: CSR) fell 11.28 percent to 770.5p.
The mining sector declined on copper prices that were lower.
Antofagasta (LSE: ANTO) was 2.47 percent lower to 723p, while Rio Tinto (LSE: RIO) was down 3.65 percent to £35.90.
On the 250, property developer Daejan Holdings (LSE: DJAN) fell 5.75 percent to £38.86, while builder Severfield-Rowen (LSE: SFR) dropped 5.69 percent to £22.36.