London’ equities markets saw substantial declines again on Monday.

The FTSE 100 was 1.69 percent lower to 6,182.8 and the FTSE 250 dropped 1.91 percent to 10,745.3.

Northern Rock (LSE: NRK) was the biggest decliner on the 100 as it fell 35.45 percent to 282.75p, followed closely by Alliance & Leicester (LSE: AL) with a drop of 31.27 percent to 600p.

Over on the 250, mortgage lender Bradford & Bingley (LSE: BB) was 15.39 percent lower to 279p.

But the worst performer on the 250 was property developer Minerva (LSE: MNR), which was down 16.34 percent to 216.25. House builders fell on the 100.

Persimmon (LSE: PSN) dropped 6.89 percent to 946p, while Barratt Developments was 7.29 percent lower to 769p.

Pubs operator Enterprise Inns dropped 7.37 percent to 578p. Back on the 250, surgical supplies company Gyrus Group (LSE: GYG) was 8.08 percent lower to 398p.

The best performer of the session on the 250 was drug maker Hikma Pharmaceuticals (LSE: HIK) with a gain of 4.68 percent to 425p.

Northern Foods (LSE: NFDS) added 4 percent to 97.5p, while rail and bus transport firm Go-Ahead Group (LSE: GOG) was up 1.66 percent to £25.18.

Software maker Sage Group (LSE: SGE) had the best day on the 100, where it gained 2.77 percent to 250p.

Medical devices manufacturer Smith & Nephew (LSE: SN) added 0.7 percent to 572p, while in the telecommunications sector BT Group (LSE: BT.A; NYSE: BT) was 0.16 percent higher to 316.75p.

London’s markets were higher Friday.

The FTSE 100 added 0.37 percent to 6,220.1, while the FTSE 250 gained 0.22 percent to 10,969.5.

Software maker Sage Group (LSE: SGE) was the best performer on the 100 with a gain of 3.21 percent to 233.25p.

But financial services groups crowded the top of the loser board on the 100.

Man Group (LSE: EMG) was 2.55 percent lower to 477.5p. Barclay’s Bank (LSE: BARC; NYSE: BCS; TYO: 8642) dropped 2.63 percent to 611p, while Standard Chartered (LSE: STAN; SEHK: 2888) was the worst performer on the 100 as it fell 4.9 percent to £14.94.

3i Group (LSE: III) was 4.26 percent lower to £10.34. Rounding out the top five decliners on the 100 was British Energy Group (LSE: BGY) with a decline of 2.67 percent to 446.75p.

Miners and the oil sector saw gains.

Rio Tinto (LSE: RIO) was up 2.36 percent to £33.39, while BG Group (LSE: BG; NYSE: BG) added 2.74 percent to 769.5p.

Retailer Sainsbury gained 2.16 percent to 544.5p.

The best performer on the 250 was Assura Group (LSE: AGR), with a gain of 13.85 percent to 160.25p.

Property developer Daejan Holdings (LSE: DJAN) was 5.08 percent higher to £36.00.

Financial services groups didn’t fare much better on the 250 than they did on the 100.

Asset manager Henderson Group (LSE: HGI; ASX: HGI) was 2.52 percent lower to 135.25p, while investment managers Rathbone Brothers (LSE: RAT) dropped 2.55 percent to £12.23.

But the worst performer on the 250 was food processor Northern Foods (LSE: NFDS) with a drop of 2.86 percent to 102p.

The London equities markets were mixed on Monday, as the FTSE 100 added 0.7 percent to 6,067.0 but the FTSE 250 declined by 0.4 percent to 9,878.9.

Miners once again were among the gainers on the day. Antofagasta was up 3.4 percent to £23.39, while Kazakhmys and Anglo American each gained 2.9 percent, to £12.35 and £24.05 respectively.

In the advertising sector, WPP added 2.7 percent to 690½p on positive comments from both Deutsche Bank and Lehman Brothers.

Media companies were also up on the day. Pearson, which owns the Financial Times, gained 2.4 percent to 781p. EMI added 2.8 percent to 257p as talk circulated that it might merge with US company Warner Music Group.

Rising crude oil prices sent BP up 1.8 percent to 693½p as traders predicted that shares in the company could go as high as 720p.

In the telecommunications sector, Vodafone gained 0.4 percent as it was rumored that Verizon, Telefonica of Spain, and the Blackstone private equity group could bid for the company.

On the other hand, word that GlaxoSmithKline will not be bought by Serono brought a gain of 1.2 percent to the largest pharmaceuticals company in Europe, bringing its share price to £14.94. Also helping GSK was an upgrade to “outperform” from Sanford C. Bernstein on the hope that it will have developed a H5N1 flu vaccine by early next year.

Losers on the day included hotels company De Vere, which lost 1.8 percent to 800p. Northern Foods declined by 3.3 percent to 95¼p on worries that bird flu concerns would impact its poultry business. Among chipmakers, Wolfson Microelectronics dropped 6.5 percent to 443p on a downgrade from Goldman Sachs.