Equities were down in London Wednesday, with the FTSE 100 down 0.49 percent to 6,482 and the FTSE 250 falling 0.71 percent to 11,278.5.

The pharmaceuticals sector saw losses.

GlaxoSmithKline (LSE: GSK; NYSE: GSK) dropped 0.9 percent to £12.49 after it reported that profits were down 5.8 percent in the third quarter on poor sales of Advair and Avandia.

Meanwhile, AstraZeneca (LSE: AZN; NYSE: AZN) fell 2 percent to £24.09 after a lowered recommendation from Merrill Lynch, which cited increased competition from generics in reducing the drug maker from “neutral” to “sell”.

Miners were also lower on declines in base metals prices.

Vedanta Resources (LSE: VED) dropped 4.05 percent to £20.63, while Lonmin (LSE: LMI) was down 4.66 percent to £32.50 and Kazakhmys (LSE: KAZ) fell 7.21 percent to £13.78 after it said output was cut by 19 percent in one of its mines after a flood.

Oil explorer and producer Cairn Energy (LSE: CNE) had the best day on the 250 with a gain of 6.35 percent to £24.13 on rumors that BP (LSE: BP; NYSE: BP; TYO: 5051) might make an offer.

Elsewhere in the oil sector, Tullow Oil (LSE: TLW; OTC: TUWLY) was up 2.09 percent to 610p.

Carphone Warehouse (LSE: CPW) gained 1.82 percent to 336.25p on news of an unexpected deal with Vodafone (LSE: VOD; NYSE: VOD; FWB: VOD) in which Vodafone will host Carphone Warehouse’s new mobile phone service.

The best performance on the 100 came from BAE Systems (LSE: BA). The aerospace and defense group added 3.36 percent to 507p.

London’s markets were lower again on Friday.

The FTSE 100 dropped 1.23 percent to 6,527.9 while FTSE 250 fell 0.98 percent to 11,299.3.

Insurer Resolution (LSE: RSL) had the best day on the 100 as it gained 2.12 percnet to 722p.

Housebuilders and the construction sector more generally were higher on both the 100 and the 250.

Persimmon (LSE: PSN) was up 1.15 percent to 971p and Barratt Developments (LSE: BDEV) was 1.29 percent higher to 667p on the 100, while over on the 250 house builder Redrow (LSE: RDW) gained 3.03 percent to 383p and construction group Alfred McAlpine (LSE: MCA) added 3.54 percent to 555p.

Other gainers included paper group DS Smith (LSE: SMPS), which was up 5.31 percent to 228p on the 250.

Brewer Scottish & Newcastle (LSE: SCTN) was 1.19 percent higher to 766.5p on the 100.

Banks were lower, with Northern Rock (LSE: NRK) again leading the losers on the 100 with a decline of 8.61 percent to 186.9p.

Elsewhere in the sector, HBOS (LSE: HBOS) dropped 2.91 percent to 835p.

In the pharmaceuticals sector Astra Zeneca (LSE: AZN; NYSE: AZN) was down 3.64 percent to £24.61 after the revocation of an inhaler patent by European authorities and a downgrade from “neutral” to “sell” by UBS.

Advertising group WPP (LSE: WPP; NAS: WPPGY) fell 4.18 percent to 665p after it reported quarterly revenues that were at the low end of expectations.

London’s markets were also higher on the session.

The FTSE 100 added 3.5 percent to 6,064.2, while the FTSE 250 was 2.14 percent higher to 10,686.2.

As on the continent, banks saw gains.

Standard Chartered (LSE: STAN; SEHK: 2888) was the best performer on the 100 as it added 8.03 percent to £15.60, while Northern Rock (LSE: NRK) was right behind with a gain of 7.66 percent to 709.5p.

Insurers were also higher, with Standard Life (LSE: SLET) up 7.01 percent to 305.5p.

Broker ICAP (LSE: IAP) was 6.48 percent higher to 484.5p.

Miners also saw gains.

Rio Tinto (LSE: RIO) gained 1.8 percent to £29.82, while BHP Billiton (LSE: BLT; NSYE; BHP; ASX: BHP) added 3.5 percent to £12.24 and Lonmin (LSE: LMI) was 6.52 percent higher to £29.74.

In the pharmaceuticals sector, AstraZeneca (LSE: AZN; NYSE: AZN) was up 2.55 percent to £23.36 while GlaxoSmithKline (LSE: GSK; NYSE: GSK) gained 3.33 percent to £12.71.

Oil and gas services group Petrofac (LSE: PFC) had the best day on the 250, where it added 7.72 percent to 418.5p, while the biggest loser there was asset manager Henderson Group (LSE: HGI; ASX: HGI) at a drop of 2.9 percent to 125.5p.

There were only two losers on the 100 on the session. Imperial Chemical Industries (LSE: ICI) dropped 0.16 percent to 616p, while retailer Tesco (LSE: TSCO) was down 0.12 percent to 403.5p.

The markets in London also saw declines as the FTSE 100 fell 1.92 percent to 6,271.2 and the FTSE 250 was 2 percent lower to 11,225.5.

Shares in the financial services sector did not do very well for the most part on the 100.

Venture capital and private equity group 3i Group (LSE: III) was 5.8 percent lower to £10.56, while insurer Standard Life (LSE: SLET) fell 6.52 percent to 318.75p and hedge fund Man Group (LSE: EMG) was down 6.73 percent to 527p.

Not all in the financial services sector saw declines however.

Alliance & Leicester (LSE: AL) added 1.17 percent to £11.20 and insurer Benfield Group (LSE: BFD) gained 4.95 percent to 339p.

Insurance broker and risk management advisor Jardine Lloyd Thompson Group (LSE: JLT) had the best day on the 100 as it added 4.95 percent to 425p.

The best performer on the 250 was BSkyB (LSE: BSY), which gained 2.58 percent to 694.4p.

Other gainers included power transmitter National Grid (LSE: NG), which was 2.09 percent higher to 731.5p.

Chemicals group Reckitt Benckiser (LSE: RB) was up 1.5 percent to £27.74.

Defense contractor BAE Systems (LSE: BA; OTCBB: BAESY) added 0.9 percent to 440.25p after it said that first half profits were up a better-than-anticipated 27 percent on upgrades to its Bradley fighting vehicles for use by the US in Iraq and on the production of jet parts.

The biggest loser on the day on the 100 was miner Kazakhmys (LSE: KAZ), which was down 6.79 percent to £11.25.

In the pharmaceuticals sector, AstraZeneca (LSE: AZN; NYSE: AZN) dropped 3.5 percent to £24.30 on a safety review of its acid reflux drugs Nexium and Prilosec after two studies linked them to heart problems.

However, the Food and Drug Administration said that it had concluded on a preliminary basis that there is no increased risk to patients taking the drugs.

London’s markets saw declines on Wednesday, with the FTSE 100 down 0.24 percent to 6,615.1 and the FTSE 250 falling 0.56 percent to 11,666.8.

Retailers were mixed on the session, with Wm Morrison (LSE: MRW) up 2.48 percent to 313.75p but Home Retail (LSE: HOME) falling 2.35 percent to 438.75p for the worst day on the 100.

Conversely, the best performer on the 100 was in the leisure sector, where Whitbread (LSE: WTB) added 7.04 percent to £19.46 on rumors that it could be targeted for bids.

Other gainers on the day included BSkyB, which added 4.17 percent to 700p.

In the oil sector, BG Group (LSE: BG; NYSE: BG) gained 2.56 percent to 842p.

The pharmaceuticals sector was mixed.

AstraZeneca (LSE: AZN; NYSE: AZN) was 2.43 percent higher to £26.95 on an upgrade from “equal-weight” to “overweight” from Morgan Stanley (NYSE: MS), while Shire (LSE: SHP; NAS: SHPGY) was down 1.97 percent to £11.97 on rumors that it might be looking to make an acquisition.

Also lower on the session was property group Hammerson (LSE: HMSO), which dropped 1.65 percent to £13.67.

British Airways (LSE: BAY; NSYE: BAB) fell 1.7 percent to 418.5p, hurt by higher oil prices.

Equities markets in London were higher on Wednesday, with both the FTSE 250 and the FTSE All-Share hitting all-time highs for the second day in a row. The 250 added 0.2 percent to 11,502, while the All-Share gained 0.2 percent as well, to 3,301.77. The FTSE 100 was also higher, up 0.4 percent to 6,369.5.

Miners saw advances on the day after BHP Billiton added 5.5 percent to £10.40 on the announcement of a new share buyback. The rest of the sector followed Billiton higher, with Anglo American gaining 2.7 percent to £24.71, Lonmin 2.8 percent higher to £31.89, and Vedanta resources adding 3.5 percent to £12.36.

J Sainsbury was 0.7 percent higher to 519½p after rumors circulated that an anonymous investor was interested in acquiring 50 million shares of the supermarket chain.

British Airways gained 4.6 percent to 574p on upgrades from Merrill Lynch, which raised its recommendation on the airline to “buy” and increased its target share price to 700p.

With 86million shares trading hands on the session, Scottish Power was 1.8 percent higher to 770p on consolidation rumors in Europe. The rumors were denied later.

In the pharmaceuticals sector, AstraZeneca dropped 1.1 percent to £29.50.

London equities markets were higher on Thursday, with the FTSE 100 1.3 percent higher to 6,282.2 on a session where it saw all of its listed stocks finish in the black. The FTSE 250 was 1.1 percent higher to 11,221.5. Trade was brisk, with 4 billion shares trading hands.

Homebuilders were higher on mergers and acquisitions rumors. Wilson Bowden gained 0.6 percent to £23, while Redrow was 1.1 percent higher to 626½p and Barratt Developments added 2.3 percent to £12.09, amid talk that Barratt could be interested in Redrow if its bid for Wilson is not successful.

In the retail sector, supermarket J Sainsbury was up 2.6 percent to 445½p on the news that Lord Sainsbury of Turville reduced his stake to 13.9 percent by selling 40 million shares.

In the pharmaceuticals sector, AstraZeneca was up 2.2 percent to £29.03 after it outlined steps it would take in order to drive growth.

While no stocks on the 100 lost ground on the day, four did close even. Three of those, steelmaker Corus, at 601½p, tobacco company Gallaher, at £11.37, and Scottish Power, at 747p, are all in the middle of mergers and acquisitions activity. The fourth company to close steady was advertiser WPP, which also ended the session at 747p.

The FTSE 100 dropped 0.6 percent to 6,269.3 in London on Thursday, while the FTSE 250 was 0.2 percent lower to 11,171.1. The 100 briefly reached a six-year high, at 6,335.1, early in the session but dropped later on the slow start in the New York markets.

Real estate was higher on the session after JP Morgan reminded that the UK sector is currently a better bargain than its European rivals. Hammerson added 0.2 percent to £15.03, while British Land was 0.6 percent higher to £16.21.

Publisher Pearson added 0.9 percent to 817½p on bids rumors and after Citigroup upped its target share price to 900p.

The pharmaceuticals sector declined after Credit Suisse said that the sector would extend its underperformance into this year after a sector-wide decline of 5.2 percent last year, mentioning the trouble companies were having bringing new drugs to market and keeping them there once introduced. Shire dropped 1 percent to £10.99, while AstraZeneca fell 1.3 percent to £28.44 and GlaxoSmithKline was 1.4 percent lower to £13.93.

In a related news, medical devices manufacturer Smith & Nephew was 1.4 percent lower to 570½p after it was suggested that its next report might not show as much of an improvement in margins as is hoped.

The FTSE 100 ended the day and the week ahead on Friday, while the FTSE 250 saw declines for both the session and this week. The 100 added 0.1 percent during the day and was 0.3 percent higher on the week to close at 6,239. Meanwhile the 250 dropped 0.1 percent on Friday and 0.7 percent on the week to 11,111.7.

The pharmaceuticals sector was helped by a vote in the US House of Representatives that would let the government negotiate directly with drug companies on the prices of drugs for Medicare recipients. GlaxoSmithKline was 0.5 percent higher to £13.71, while AstraZeneca gained 1.3 percent to £28.73.

Bids rumors sent Woolworths up 3 percent to 34p. Baugur, which currently owns 10 percent of the retailer, is said to be considering offering a bid of 40p per share. Ladbrokes was helped by talk of a possible bid from private equity, gaining 2.4 percent to 449¼p.

In the oil sector, BP was 1.8 percent higher to 546½p on the news that its chief executive will retire in July, to be replaced by the company’s head of exploration and production.

Lloyds TSB added 1.7 percent to 593p on the possibility that its dividend could go up and after Cazenove upped its recommendation to “outperform”.

London’s equities markets were mixed on Friday. The FTSE 100 dropped 0.5 percent to close at 6,021.5 after falling as low as 5,985.2 during the day, bringing its decline over the week to 1.6 percent. On the other hand, the FTSE 250 added 0.2 percent on the session and was up by the same amount for the week, to close at 10,698.9.

Miners were higher, with Xstrata 2 percent higher to £23.26 and Antofagtasta adding 3.2 percent to 495p as Goldman Sachs predicted that commodities prices will be going up further. The broker put Xstrata on its “conviction buy” list.

Leisure group Rank dropped 2.9 percent to 270p after a rumored bid was not forthcoming and Citigroup downgraded it to “hold”. Meanwhile, cruise operator Carnival fell 1.9 percent to £24.29 on a reduced recommendation, from “buy” to “hold”, from Merrill Lynch.

In the pharmaceuticals sector, AstraZeneca dropped 2.1 percent to £28.90 as sterling gained ground over the US dollar.

Among insurance companies, Legal & General fell 2.2 percent to 148½p as bids rumors faded.

Construction materials group Hanson was 1.4 percent lower to 719p.

Bucking the trend among the blue-chips, Cairn Energy added 4.4 percent to £20.57. Cairn is preparing to spin off its India unit with an initial public offering in Bombay later this month. That IPO is estimated to be worth as much as $7.5 billion (£3.8 billion). In addition, there was talk that Cairn’s Indian partner, ONGC, might be interested in acquiring Cairn’s assets in Rajasthan.