Equities were down in London Wednesday, with the FTSE 100 down 0.49 percent to 6,482 and the FTSE 250 falling 0.71 percent to 11,278.5.
The pharmaceuticals sector saw losses.
GlaxoSmithKline (LSE: GSK; NYSE: GSK) dropped 0.9 percent to £12.49 after it reported that profits were down 5.8 percent in the third quarter on poor sales of Advair and Avandia.
Meanwhile, AstraZeneca (LSE: AZN; NYSE: AZN) fell 2 percent to £24.09 after a lowered recommendation from Merrill Lynch, which cited increased competition from generics in reducing the drug maker from “neutral” to “sell”.
Miners were also lower on declines in base metals prices.
Vedanta Resources (LSE: VED) dropped 4.05 percent to £20.63, while Lonmin (LSE: LMI) was down 4.66 percent to £32.50 and Kazakhmys (LSE: KAZ) fell 7.21 percent to £13.78 after it said output was cut by 19 percent in one of its mines after a flood.
Oil explorer and producer Cairn Energy (LSE: CNE) had the best day on the 250 with a gain of 6.35 percent to £24.13 on rumors that BP (LSE: BP; NYSE: BP; TYO: 5051) might make an offer.
Elsewhere in the oil sector, Tullow Oil (LSE: TLW; OTC: TUWLY) was up 2.09 percent to 610p.
Carphone Warehouse (LSE: CPW) gained 1.82 percent to 336.25p on news of an unexpected deal with Vodafone (LSE: VOD; NYSE: VOD; FWB: VOD) in which Vodafone will host Carphone Warehouse’s new mobile phone service.
The best performance on the 100 came from BAE Systems (LSE: BA). The aerospace and defense group added 3.36 percent to 507p.