In London on Thursday the FTSE 100 was 0.57 percent lower to 6,635.2, while the FTSE 250 fell 0.27 percent to 11,802.8.
The declines came after the Bank of England’s Monetary Policy Committee voted to raise interest rates to 5.75 percent.
Miners were helped by continuing merger rumors and by metals prices which remained strong.
Rio Tinto (LSE: RIO) was 1.45 percent higher to £40.01, while BHP Billiton (LSE: BLT; ASX: BHP; NYSE: BHP) gained 1.74 percent to £14.62.
Xstrata (LSE: XTA) had the best day on the 100, adding 1.96 percent to £31.70.
Computer software and video games retailer GAME Group (LSE: EBQ) was the best performer on the 250, gaining 7.14 percent to 195p, while employment recruiter Michael Page International (LSE: MPI) was 6.34 percent higher to 595p.
The telecommunications sector took losses on the 100 after it was reported that Vodafone (LSE: VOD; NYSE: VOD; FWB: VOD) had not won an exclusive contract to partner with Apple (NAS: AAPL; LSE: ACP; FWB: APC) on its iPhone in the UK.
Vodafone dropped 2.41 percent to 162.1p, while BT Group (LSE: BT.A; NSYE: BT) was 2.38 percent lower to 328.75p.
Construction materials group Wolseley (LSE: WOS)had the worst day on the 100 as it dropped 2.63 percent to £11.83.